SUPPRESSION OF ADJUVANT-INDUCED ARTHRITIS IN DA RATS BY INCOMPLETE FREUND ADJUVANT

被引：11

作者：

CANNON, GW

GRIFFITHS, MM

WOODS, ML

机构：

[1] UNIV UTAH,DEPT MED,DIV INFECT DIS,SALT LAKE CITY,UT 84132

[2] SALT LAKE CITY VET AFFAIRS MED CTR,SALT LAKE CITY,UT

来源：

ARTHRITIS AND RHEUMATISM | 1993年 / 36卷 / 01期

关键词：

D O I：

10.1002/art.1780360120

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To define the effects of incomplete Freund's adjuvant (ICFA) on subsequent arthritis induced by complete Freund's adjuvant (CFA) and type II collagen (CII) in DA and Lewis rats. Methods. ICFA was in injected into DA and Lewis rats before CFA or CII injection. Results. DA rats previously injected with ICFA had significantly less severe arthritis induced by CFA compared with those not receiving ICFA pretreatment (P < 0.01). ICFA had no significant impact on CFA-induced arthritis in Lewis rats or on CII-induced arthritis in DA rats. Conclusion. The injection of ICFA alone specifically suppresses subsequent CFA-induced arthritis in DA rats, but not in Lewis rats.

引用

页码：126 / 131

页数：6

共 14 条

[1] A MYCOBACTERIAL 65-KD HEAT-SHOCK PROTEIN INDUCES ANTIGEN-SPECIFIC SUPPRESSION OF ADJUVANT ARTHRITIS, BUT IS NOT ITSELF ARTHRITOGENIC [J].