HYPERACTIVITY IN PREWEANLING RATS FOLLOWING POSTNATAL ALCOHOL EXPOSURE

被引：32

作者：

MELCER, T ^{[1
]}

GONZALEZ, D ^{[1
]}

BARRON, S ^{[1
]}

RILEY, EP ^{[1
]}

机构：

[1] UNIV KENTUCKY,LEXINGTON,KY

来源：

ALCOHOL | 1994年 / 11卷 / 01期

关键词：

POSTNATAL ALCOHOL EXPOSURE; HYPERACTIVITY; PREWEANLING RATS; FAS;

D O I：

10.1016/0741-8329(94)90010-8

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Neonatal alcohol exposure in rats has been used as a model to study the effects of third-trimester alcohol consumption in humans. In the present research, male and female rat pups were artificially reared (AR) and received condensed alcohol exposure (6 g/kg/day or 4 g/kg/day) on postnatal days (PNs)4 through 9. Controls consisted of both artificially reared animals receiving maltose-dextrin substituted for alcohol and normally reared animals. These rats were tested for open-field activity at 18 days of age for four days. Both male and female rat pups that received the high dose of alcohol (6 g/kg/day) evidenced overactivity relative to pups in both control groups. These findings extend previous work and indicate that neonatal alcohol exposure can induce hyperactivity in young male rats.

引用

页码：41 / 45

页数：5

共 20 条

[1] EFFECTS OF PRENATAL ALCOHOL EXPOSURE ON NOSE POKING IN YEAR-OLD RATS [J].