SELECTIVE EXPANSION OF T-CELLS EXPRESSING V-BETA-2 IN PEANUT ALLERGY

被引：13

作者：

DORION, BJ

LEUNG, DYM

机构：

[1] NATL JEWISH CTR IMMUNOL & RESP MED,DEPT PEDIAT,DENVER,CO 80206

[2] UNIV COLORADO,HLTH SCI CTR,DENVER,CO 80262

来源：

PEDIATRIC ALLERGY AND IMMUNOLOGY | 1995年 / 6卷 / 02期

关键词：

PEANUT; ALLERGY; T CELLS;

D O I：

10.1111/j.1399-3038.1995.tb00266.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Peanuts are the most common cause of fatal and near-fatal food-induced anaphylaxis, The immune basis for susceptibility to peanut allergy is poorly understood. The current study examined the possibility that patients with peanut allergy, as compared to normals, use different T cell receptor variable beta regions (V beta) in the recognition of peanuts. The results demonstrate that stimulation of T cells from patients with peanut allergy results in the selective expansion of V beta 2(+) T cells.

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页码：95 / 97

页数：3

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