INHIBITION OF PIGEON BREAST MUSCLE ALPHA-KETOGLUTARATE DEHYDROGENASE BY PHOSPHONATE ANALOGS OF ALPHA-KETOGLUTARATE

被引：25

作者：

BUNIK, VI ^{[1
]}

BIRYUKOV, AI ^{[1
]}

ZHUKOV, YN ^{[1
]}

机构：

[1] ACAD SCI USSR,INST MOLEC BIOL,MOSCOW 117984,USSR

来源：

FEBS LETTERS | 1992年 / 303卷 / 2-3期

关键词：

ALPHA-KETOGLUTARATE DEHYDROGENASE; TRANSITION STATE ANALOG; SUCCINYLPHOSPHONATE; SLOW ISOMERIZATION;

D O I：

10.1016/0014-5793(92)80518-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Succinylphosphonate (SP) is a powerful inhibitor of alpha-ketoglutarate dehydrogenase (KGD). Methylation of the phosphonate reduces its inhibitory effect. The complex of KGD with SP undergoes a kinetically slow transition similar to the process observed during catalysis. Alpha-ketoglutarate binds to the enzyme-inhibitor complex, preventing its isomerisation.

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页码：197 / 201

页数：5

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