GROWTH-HORMONE (GH) SECRETION FROM HUMAN-LYMPHOCYTES IS UP-REGULATED BY GH, BUT NOT AFFECTED BY INSULIN-LIKE GROWTH FACTOR-I

被引:33
作者
HATTORI, N
SHIMOMURA, K
ISHIHARA, T
MORIDERA, K
HINO, M
IKEKUBO, K
KURAHACHI, H
机构
[1] KOBE CITY GEN HOSP, DEPT NUCL MED, KOBE, JAPAN
[2] FUJISAWA PHARMACEUT CO LTD, PROD DEV LAB, OSAKA 532, JAPAN
关键词
D O I
10.1210/jc.76.4.937
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Regulation of GH secretion from phytohemagglutinin (PHA)-stimulated lymphocytes was investigated in six normal subjects. Peripheral blood mononuclear cells were incubated with PHA (10 mug/mL) in the presence of various amounts of recombinant human GH (0-100 ng/L) and/or recombinant human insulin-like growth factor-I (0-1000 mug/L), and the secreted GH was measured by a highly sensitive enzyme immunoassay. PHA-stimulated lymphocytes secreted immunoreactive GH in all subjects (13.6 +/- 2.4 ng/L). Exogenous GH up-regulated the GH secretion in a dose-dependent manner, while IGF-I did not affect either basal GH secretion or the up-regulation by exogenous GH. These findings suggest a difference in the regulation of GH secretion between endocrine and immune systems.
引用
收藏
页码:937 / 939
页数:3
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