MATRIX-ASSISTED LASER DESORPTION/IONIZATION MASS-SPECTROMETRY OF SYNTHETIC OLIGODEOXYRIBONUCLEOTIDES

被引:74
作者
PARR, GR [1 ]
FITZGERALD, MC [1 ]
SMITH, LM [1 ]
机构
[1] UNIV WISCONSIN, DEPT CHEM, MADISON, WI 53706 USA
关键词
D O I
10.1002/rcm.1290060603
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry has been used to mass analyze a variety of synthetic oligodeoxyribonucleotides ranging in size from 6 to 30 nucleotides. Molecular ions were observed almost exclusively, with little or no fragmentation and generally minor contributions from multiply charged species. Mixtures of poly d(T)12-30 with low picomole amounts of each component gave well resolved peaks. These results are encouraging for the concept of DNA sequence analysis by mass spectrometry.
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页码:369 / 372
页数:4
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