PHOTODYNAMIC ACTIVITY OF CHLORIN-E(6) AND CHLORIN-E(6) ETHYLENEDIAMIDE INVITRO AND INVIVO

被引：32

作者：

GURINOVICH, GP

ZORINA, TE

MELNOV, SB

MELNOVA, NI

GURINOVICH, IF

GRUBINA, LA

SARZHEVSKAYA, MV

CHERENKEVICH, SN

机构：

[1] BYELORUSSIAN STATE UNIV,MINSK 220080,BELORUSSIA,USSR

[2] BYELORUS ACAD SCI,INST GENET & CYTOL,MINSK 220734,BELORUSSIA,USSR

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1992年 / 13卷 / 01期

关键词：

PORPHYRINS; CHLORINS; SENSITIZERS; PHOTOTHERAPY; PHOTOCYTOTOXICITY; ACCUMULATION; TUMOR; CELL; TISSUE;

D O I：

10.1016/1011-1344(92)80039-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several parameters of chlorin e6 and its derivative chlorin e6 ethylenediamide have been investigated as these compound are potential sensitizers for photodynamic therapy. A study carried out to compare the cellular uptake of the pigments indicates that chlorin e6 ethylenediamide possesses an enhanced affinity for tumour cells and cellular membranes. Comparison of the uptake in induced sarcoma shows that chlorin e6 ethylenediamide is a much better tumour localizer than chlorin e6. The efficiency of phototherapy with chlorin e6 ethylenediamide is higher than that with chlorin e6. These data show the influence of the substitution of the carboxyl groups in chlorin e6 by ester and amide groups on the photosensitizing properties of the pigments.

引用

页码：51 / 57

页数：7

共 16 条

[1] PHOTODYNAMIC THERAPY WITH PORPHYRIN AND PHTHALOCYANINE SENSITIZATION - QUANTITATIVE STUDIES IN NORMAL RAT-LIVER [J].