SIMPLE AND EFFICIENT CONVERSION OF N,N-DIMETHYLHYDRAZONES AND ALDEHYDES TO NITRILES

被引：81

作者：

FERNANDEZ, R

GASCH, C

LASSALETTA, JM

LLERA, JM

VAZQUEZ, J

机构：

[1] UNIV SEVILLA,DEPT QUIM ORGAN,APARTADO CORREOS 553,E-41071 SEVILLE,SPAIN

[2] UNIV SEVILLA,DEPT QUIM ORGAN & FARMACEUT,E-41080 SEVILLE,SPAIN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 01期

关键词：

NITRILES; N; N-DIALKYLHYDRAZONES; MAGNESIUM MONOPEROXYPHTALATE; ALDEHYDES;

D O I：

10.1016/S0040-4039(00)60078-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aldehyde N,N-dimethylhydrazones undergo facile oxidative cleavage to nitriles on reaction with magnesium monoperoxyphtalate hexabydrate (MMPP) under very mild conditions. The reaction is high yielding, chemoselective and proceeds rapidly without racemization. Nitriles can be easily obtained in high yields in a 'one-pot' process starting from the corresponding aldehydes.

引用

页码：141 / 144

页数：4

共 20 条

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