STRONG IMMUNOREACTIVITY OF BETA-AMYLOID PRECURSOR PROTEIN, INCLUDING THE BETA-AMYLOID PROTEIN-SEQUENCE, AT HUMAN NEUROMUSCULAR-JUNCTIONS

被引:62
作者
ASKANAS, V
ENGEL, WK
ALVAREZ, RB
机构
[1] USC Neuromuscular Center, University of Southern California School of Medicine, Los Angeles
关键词
BETA-AMYLOID PRECURSOR PROTEIN; BETA-AMYLOID PROTEIN; HUMAN NEUROMUSCULAR JUNCTION;
D O I
10.1016/0304-3940(92)90241-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
At the postsynaptic domain of the human neuromuscular junction (NMJ), we have demonstrated strong concentrations of the N-terminus 45 62, C-terminus 676-695 and beta-amyloid protein sequences of beta-amyloid precursor protein (beta-APP). We used well-characterized monoclonal and polyclonal antibodies for co-localization with three other postsynaptic proteins, applying double and triple fluorescence labeling. Strong immunoreactivity of all three beta-APP sequences was found at all NMJs identified by bound alpha-bungarotoxin (alpha-BT), where they co-localized with alpha-BT and with immunoreactive desmin and dystrophin, which are postsynaptic proteins of human NMJs. This appears to be the first demonstration of beta-APP sequences concentrated postsynaptically at human NMJs. Beta-APP may have a role in normal junctional biology and possibly in some diseases affecting NMJs.
引用
收藏
页码:96 / 100
页数:5
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