COMPARISON OF SYSTEMIC AND MUCOSAL PRIMING FOR MUCOSAL IMMUNE-RESPONSES TO A BACTERIAL PROTEIN ANTIGEN GIVEN WITH OR COUPLED TO CHOLERA-TOXIN (CT) B-SUBUNIT, AND EFFECTS OF PREEXISTING ANTI-CT IMMUNITY

被引：27

作者：

WU, HY ^{[1
]}

RUSSELL, MW ^{[1
]}

机构：

[1] UNIV ALABAMA, DEPT MICROBIOL, BIRMINGHAM, AL 35294 USA

来源：

VACCINE | 1994年 / 12卷 / 03期

关键词：

MUCOSAL IMMUNE RESPONSE; CHOLERA TOXIN; B SUBUNIT; PROTEIN ANTIGEN; IMMUNIZATION ROUTES;

D O I：

10.1016/0264-410X(94)90197-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intraperitoneal immunization with a bacterial protein antigen conjugated to cholera toxin B subunit (CTB) was generally less effective than intragastric ol intranasal immunization in generating mucosal IgA antibodies, and in priming the mucosal immune system to respond to intragastric or intranasal boosting. Previous intragastric or intranasal immunization which generated high levels of mucosal and circulating antibodies to CTB did not suppress mucosal IgA responses induced by intragastric os intranasal immunization with bacterial antigen conjugated to or mixed with CTB, but serum antibody responses were inhibited depending on the route of immunization and whether CTB was conjugated to or mixed with the antigen.

引用

页码：215 / 222

页数：8

共 41 条

[1]

BROMANDER A, 1991, J IMMUNOL, V146, P2908

[2]

CHALLACOMBE SJ, 1978, IMMUNOLOGY, V35, P923

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