MYCOBACTERIUM-AVIUM STRAINS RESISTANT TO CLARITHROMYCIN AND AZITHROMYCIN

被引：99

作者：

HEIFETS, L ^{[1
]}

MOR, N ^{[1
]}

VANDERKOLK, J ^{[1
]}

机构：

[1] UNIV COLORADO,HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL,DENVER,CO 80262

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 11期

关键词：

D O I：

10.1128/AAC.37.11.2364

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mycobacterium avium strains susceptible to clarithromycin and azithromycin contain mutants resistant to these macrolides with a frequency of 1.1 x 10(-10) to 1.2 x 10(-6). Cross-resistance between clarithromycin and azithromycin was demonstrated with mutants selected in the laboratory as well as with resistant strains isolated from patients. The susceptibility-resistance patterns of the macrolide-resistant strains with drugs other than macrolides were the same as those of the original susceptible strains. The emergence of clarithromycin resistance in patients was a result of multiplication of the preexisting resistant mutants that survived the elimination of bacteria during the initial period of treatment and was an exclusive cause of the relapse of bacteremia.

引用

页码：2364 / 2370

页数：7

共 26 条

[1] THE NEW MACROLIDE ANTIBIOTICS - AZITHROMYCIN, CLARITHROMYCIN, DIRITHROMYCIN, AND ROXITHROMYCIN
BAHAL, N
NAHATA, MC
[J]. ANNALS OF PHARMACOTHERAPY, 1992, 26 (01) : 46 - 55
[2] ACTIVITIES OF CLARITHROMYCIN AGAINST 8 SLOWLY GROWING SPECIES OF NONTUBERCULOUS MYCOBACTERIA, DETERMINED BY USING A BROTH MICRODILUTION MIC SYSTEM
BROWN, BA
WALLACE, RJ
ONYI, GO
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (09) : 1987 - 1990
[3] CHAISSON RE, 1992, 32ND INT C ANT AG CH
[4] ACTIVITY OF CLARITHROMYCIN AGAINST MYCOBACTERIUM-AVIUM INFECTION IN PATIENTS WITH ACQUIRED-IMMUNE-DEFICIENCY-SYNDROME - A CONTROLLED CLINICAL-TRIAL
DAUTZENBERG, B
TRUFFOT, C
LEGRIS, S
MEYOHAS, MC
BERLIE, HC
MERCAT, A
CHEVRET, S
GROSSET, J
[J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (03): : 564 - 569
[5] DAUTZENBERG B, 1991, 31ST INT C ANT AG CH
[6] DAUTZENBERG B, 1992, FRONTIERS MYCOBACTER
[7] INVITRO AND INVIVO ACTIVITIES OF CLARITHROMYCIN AGAINST MYCOBACTERIUM-AVIUM
FERNANDES, PB
HARDY, DJ
MCDANIEL, D
HANSON, CW
SWANSON, RN
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (09) : 1531 - 1534
[8] FORBEE SH, 1960, AM REV RESPIR DIS, V82, P824
[9] COMPARATIVE ANTIMYCOBACTERIAL ACTIVITIES OF DIFLOXACIN, TEMAFLOXACIN, ENOXACIN, PEFLOXACIN, REFERENCE FLUOROQUINOLONES, AND A NEW MACROLIDE, CLARITHROMYCIN
GORZYNSKI, EA
GUTMAN, SI
ALLEN, W
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (04) : 591 - 592
[10] GUPTA SK, 1992, 32ND NT C ANT AG CH

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