THE EFFECTS OF GLUCAGON-LIKE PEPTIDE-I (GLP-I) ON HORMONE-SECRETION FROM ISOLATED HUMAN PANCREATIC-ISLETS

被引：59

作者：

FEHMANN, HC ^{[1
]}

HERING, BJ ^{[1
]}

WOLF, MJ ^{[1
]}

BRANDHORST, H ^{[1
]}

BRANDHORST, D ^{[1
]}

BRETZEL, RG ^{[1
]}

FEDERLIN, K ^{[1
]}

GOKE, B ^{[1
]}

机构：

[1] UNIV GIESSEN,DEPT MED,GIESSEN,GERMANY

来源：

PANCREAS | 1995年 / 11卷 / 02期

关键词：

GLUCAGON-LIKE PEPTIDE-I(GLP-I); HORMONE SECRETION; HUMAN PANCREATIC ISLETS; INSULIN; GLUCAGON; SOMATOSTATIN;

D O I：

10.1097/00006676-199508000-00014

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Glucagon-like peptide-I (GLP-I) is a potent incretin hormone that is now considered as a new therapeutic tool in the treatment of diabetes mellitus. In this study we characterized the effects of GLP-I on peptide hormone release from isolated human pancreatic islets. GLP-I stimulated insulin release in the presence of 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 166%; 10 mM glucose + 10 nM GLP-I, 222%) but had only a weak insulinotropic effect (128%) at 2.8 mM glucose. Glucagon release was inhibited by 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 72%) and by 10 nM GLP-I at 2.8 mM glucose (67%). Somatostatin secretion was increased by 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 166%). GLP-I stimulated somatostatin release in the presence of 2.8 mM glucose (172%). Pancreatic polypeptide (PP) secretion was enhanced by 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 236%), GLP-I induced PP release only in the presence of 2.8 mM glucose (184%).

引用

页码：196 / 200

页数：5

共 24 条

[1] GLUCAGON-LIKE PEPTIDE - A THERAPEUTIC GLIMMER [J].