BIOCHEMICAL EFFECTS IN PATIENTS WITH CALCIUM-OXALATE STONE DISEASE DURING COMBINED TREATMENT WITH BENDROFLUMETHIAZIDE AND MAGNESIUM-OXIDE

Patients (13) with calcium oxalate stone disease were treated with 2.5 mg bendroflumethiazide and 200 mg magnesium oxide twice daily for 1 yr, and the effects on serum and urine constituents were evaluated. Serum Mg and K decreased; urate increased during treatment. The association of decreased urinary Ca and increased urinary Mg resulted in a reduced Ca/Mg quotient and apparently a lower risk of forming urine supersaturated with Ca oxalate. Combined treatment with a thiazide and Mg appears to alter the composition of urine in a way that might be more favorable than treatment wiht either substance alone.