ROLE OF CERULOPLASMIN IN INFLAMMATION - INCREASED SERUM CERULOPLASMIN LEVELS DURING INFLAMMATORY CONDITIONS AND ITS POSSIBLE RELATIONSHIP WITH ANTI-INFLAMMATORY AGENTS

被引：24

作者：

DESHMUKH, VK ^{[1
]}

RAMAN, PH ^{[1
]}

DHULEY, JN ^{[1
]}

NAIK, SR ^{[1
]}

机构：

[1] HINDUSTAN ANTIBIOT LTD, CTR ANTIBIOT RES, DIV PHARMACOL & TOXICOL, PUNE 411018, INDIA

来源：

PHARMACOLOGICAL RESEARCH COMMUNICATIONS | 1985年 / 17卷 / 07期

关键词：

D O I：

10.1016/0031-6989(85)90070-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Serum ceruloplasmin (CPN) levels under different types of acute and chronic experimentally-induced inflammatory conditions in rats and the effect of anti-inflammatory drugs, i.e., oxyphenylbutazone and hydrocortisone, on serum CPN levels were investigated. Significant increase of serum CPN levels was observed in all experimental animal models with induced inflammatory conditions. Treatment with oxyphenylbutazone and hydrocortisone failed to inhibit the raised serum CPN levels. The concurrent increase of serum CPN level during induced inflammatory conditions suggest the involvement of serum CPN as one of the body''s inbuilt defensive mechanism against noxious responses or inflammation. The increased serum CPN levels may be a complimentary factor associated with inflammatory conditions.

引用

页码：633 / 642

页数：10

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