A PHYSIOLOGICAL STUDY OF THE PRENATAL DEVELOPMENT OF CUTANEOUS SENSORY INPUTS TO DORSAL HORN CELLS IN THE RAT

被引:38
作者
FITZGERALD, M
机构
[1] Department of Anatomy and Developmental Biology, University College London
来源
JOURNAL OF PHYSIOLOGY-LONDON | 1991年 / 432卷
关键词
D O I
10.1113/jphysiol.1991.sp018395
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1. The response of fetal dorsal horn cells to natural and electrical stimulation of the skin of the hindpaw was recorded in vivo from the lumbar spinal cord of anaesthetized rat fetuses still in contact with their mother via the maternal circulation. 2. Responses to electrical stimulation were obtained from embryonic day 17 (E17) but spikes were not evoked by natural skin stimulation until embryonic day 19 (E19). 3. At E19 responses were evoked by pressure or pinching the skin, but responses to low intensity brush and touch were not clear until E20. 4. Receptive fields were small and response amplitudes and frequencies initially very low. However, by E20 bursts of up to fifty spikes were recorded to a single pinch and some cells displayed responses that outlasted the stimulus by 10-15 s. 5. The development of dorsal horn cutaneous evoked spike activity and consequently the ability to transmit cutaneous sensory information to the brain therefore occurs some 2 days after the development of peripheral afferent receptive fields. It is concluded that this represents the maturation time for central synaptic connections.
引用
收藏
页码:473 / 482
页数:10
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