DEPRESSION OF DRUG-METABOLIZING ACTIVITY IN THE HUMAN LIVER BY INTERFERON-ALPHA

被引：42

作者：

OKUNO, H

KITAO, Y

TAKASU, M

KANO, H

KUNIEDA, K

SEKI, T

SHIOZAKI, Y

SAMESHIMA, Y

机构：

[1] Third Department of Internal Medicine, Kansai Medical University, Osaka, Moriguchi

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 39卷 / 04期

关键词：

7-alkoxycoumarin O-dealkylation; drug metabolism; hepatitis B; human liver biopsy; interferon-α;

D O I：

10.1007/BF00315411

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The depressant effect of interferon-α on drug metabolizing activity in the liver has been investigated in 12 patients with chronic active hepatitis B. 7-methoxy-coumarin (7-MC) O-demethylase and 7-ethoxycoumarin (7-EC) O-deethylase, in specimens obtained by liver biopsy, were measured before and after interferon treatment. 7-MC and 7-EC O-dealkylase activity were significantly reduced after interferon treatment, from 13.4 to 9.24 nmol·g-1 liver·min-1, and from 3.22 to 2.16 nmol·g-1 liver·min-1, respectively. The magnitude of the fall varied widely between individual patients. The study provides the first direct evidence that interferon-α can impair the activity of drug metabolizing enzymes in the human liver. © 1990 Springer-Verlag.

引用

页码：365 / 367

页数：3

共 16 条

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