EXCLUDED VOLUME EFFECTS ON THE KINETIC ASSEMBLING OF A STRUCTURAL MOTIF FOR RNA CATALYSIS

被引：5

作者：

FERNANDEZ, A

机构：

[1] MED SCH MIAMI,DEPT BIOCHEM & MOLEC BIOL,MIAMI,FL 33101

[2] MAX PLANCK INST BIOPHYS CHEM,BIOCHEM KINET ABT,W-3400 GOTTINGEN,GERMANY

来源：

CHEMICAL PHYSICS LETTERS | 1991年 / 183卷 / 06期

关键词：

D O I：

10.1016/0009-2614(91)80165-T

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We establish the role of excluded volume effects on the loss of conformational entropy due to pseudoknot formation in RNA. This pseudoknot appears to be the structural motif responsible for shaping the splicing site of certain noncoding RNA transcriptional products. Focusing on the illustrative example of the YC4 intron, we show that the emergence of this motif is kinetically driven and prevails over competing catalytically inert secondary structure due to excluded volume effects which favor the correlation of interacting intramolecular loops.

引用

页码：499 / 504

页数：6

共 12 条

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