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A PROBLEM WITH QUANTITATION OF MEPHENYTOIN ENANTIOMERS DUE TO CHIRAL INTERFERENCE FROM ITS N-DEMETHYLATED METABOLITE

被引：4
作者：
AKRAWI, SH [1 ]
WEDLUND, PJ [1 ]
机构：
[1] UNIV KENTUCKY,COLL PHARM,DIV PHARMACEUT & PHARMACEUT ANAL,LEXINGTON,KY 40536
来源：
JOURNAL OF CHROMATOGRAPHY | 1986年 / 381卷 / 01期
关键词：
D O I：
10.1016/S0378-4347(00)83582-3
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
引用
收藏
页码：198 / 200
页数：3
相关论文
共 6 条
[1]  
KUPFER A, 1979, J PHARMACOL EXP THER, V209, P190
[2]   ANALYSIS OF HYDROXYLATED AND DEMETHYLATED METABOLITES OF MEPHENYTOIN IN MAN AND LABORATORY-ANIMALS USING GAS-LIQUID-CHROMATOGRAPHY AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].
KUPFER, A ;
JAMES, R ;
CARR, K ;
BRANCH, R .
JOURNAL OF CHROMATOGRAPHY, 1982, 232 (01) :93-100
[3]  
KUPFER A, 1981, J PHARMACOL EXP THER, V218, P193
[4]  
KUPFER A, 1982, J PHARMACOL EXP THER, V221, P590
[5]   DIRECT ENANTIOMERIC RESOLUTION OF MEPHENYTOIN AND ITS N-DEMETHYLATED METABOLITE IN PLASMA AND BLOOD USING CHIRAL CAPILLARY GAS-CHROMATOGRAPHY [J].
WEDLUND, PJ ;
SWEETMAN, BJ ;
MCALLISTER, CB ;
BRANCH, RA ;
WILKINSON, GR .
JOURNAL OF CHROMATOGRAPHY, 1984, 307 (01) :121-127
[6]   MEASUREMENT OF MEPHENYTOIN (3-METHYL-5-ETHYL-5-PHENYLHYDANTOIN) AND ITS DEMETHYLATED METABOLITE BY SELECTIVE ION MONITORING [J].
YONEKAWA, W ;
KUPFERBERG, HJ .
JOURNAL OF CHROMATOGRAPHY, 1979, 163 (02) :161-167
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