ATTENUATED NEUROPATHOLOGY BY NILVADIPINE AFTER MIDDLE CEREBRAL-ARTERY OCCLUSION IN RATS

被引：45

作者：

KAWAMURA, S ^{[1
]}

SHIRASAWA, M ^{[1
]}

FUKASAWA, H ^{[1
]}

YASUI, N ^{[1
]}

机构：

[1] RES INST BRAIN & BLOOD VESSELS,DEPT PATHOL,AKITA,JAPAN

来源：

STROKE | 1991年 / 22卷 / 01期

关键词：

CALCIUM CHANNEL BLOCKERS; CEREBRAL ISCHEMIA; RATS;

D O I：

10.1161/01.STR.22.1.51

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated the effects of nilvadipine, a calcium antagonist, on cerebral ischemia in rats. Under halothane anesthesia, 30 rats had a 3-0 nylon suture introduced through the extracranial internal carotid artery to occlude the left middle cerebral artery. Nilvadipine was dissolved in polyethylene glycol 400. Immediately following occlusion, group 1 rats (n = 10) were treated subcutaneously with vehicle and group 2 and 3 rats were treated with 1.0 (n = 10) and 3.2 (n = 10) mg/kg nilvadipine, respectively. Perfusion fixation was performed 24 hours later, and the histopathologic outcomes were quantified. In group 1 infarct volume was 28.2 +/- 11.4% of the total cerebral volume; in groups 2 and 3 infarct volumes were 25.5 +/- 11.6% (NS) and 13.9 +/- 9.2% (p < 0.05 different from group 1), respectively. Nilvadipine decreased ischemic neuronal injury in a dose-dependent manner and may be of use in the treatment of cerebral ischemia.

引用

页码：51 / 55

页数：5

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