ATTENUATED NEUROPATHOLOGY BY NILVADIPINE AFTER MIDDLE CEREBRAL-ARTERY OCCLUSION IN RATS

被引:45
作者
KAWAMURA, S [1 ]
SHIRASAWA, M [1 ]
FUKASAWA, H [1 ]
YASUI, N [1 ]
机构
[1] RES INST BRAIN & BLOOD VESSELS,DEPT PATHOL,AKITA,JAPAN
关键词
CALCIUM CHANNEL BLOCKERS; CEREBRAL ISCHEMIA; RATS;
D O I
10.1161/01.STR.22.1.51
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We investigated the effects of nilvadipine, a calcium antagonist, on cerebral ischemia in rats. Under halothane anesthesia, 30 rats had a 3-0 nylon suture introduced through the extracranial internal carotid artery to occlude the left middle cerebral artery. Nilvadipine was dissolved in polyethylene glycol 400. Immediately following occlusion, group 1 rats (n = 10) were treated subcutaneously with vehicle and group 2 and 3 rats were treated with 1.0 (n = 10) and 3.2 (n = 10) mg/kg nilvadipine, respectively. Perfusion fixation was performed 24 hours later, and the histopathologic outcomes were quantified. In group 1 infarct volume was 28.2 +/- 11.4% of the total cerebral volume; in groups 2 and 3 infarct volumes were 25.5 +/- 11.6% (NS) and 13.9 +/- 9.2% (p < 0.05 different from group 1), respectively. Nilvadipine decreased ischemic neuronal injury in a dose-dependent manner and may be of use in the treatment of cerebral ischemia.
引用
收藏
页码:51 / 55
页数:5
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