EXTENDED IN-VIVO BLOOD-CIRCULATION TIME OF FLUORINATED LIPOSOMES

被引：63

作者：

SANTAELLA, C ^{[1
]}

FREZARD, F ^{[1
]}

VIERLING, P ^{[1
]}

RIESS, JG ^{[1
]}

机构：

[1] UNIV NICE,FAC SCI,CHIM MOLEC LAB,CNRS,URA 426,F-06108 NICE 02,FRANCE

来源：

FEBS LETTERS | 1993年 / 336卷 / 03期

关键词：

FLUORINATED LIPOSOME; FLUORINATED MEMBRANE; BLOOD CLEARANCE; CIRCULATION HALF-LIFE; LIPOPHOBICITY; INTRAVASCULAR PERSISTENCE;

D O I：

10.1016/0014-5793(93)80860-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The clearance from blood circulation of fluorinated liposomes made with perfluoroalkylated phosphatidylcholines was investigated in mice using liposome-entrapped 5(6)-carboxyfluorescein. The presence of a fluorinated core inside the membrane strongly retards their blood clearance. The fluorinated vesicles showed circulation half-lives of up to 8.6 h, which are 6-13 and 3-6 times larger than those of similarly sized conventional distearoylphosphalidylcholine and distearoylphosphatidylcholine\cholesterol liposomes, respectively. Their blood clearance was similar to that of some polyethylene glycol (PEG)-labelled 'stealth' liposomes and was dose-independent in a 3.3-330 mu moI/kg body weight dose range.

引用

页码：481 / 484

页数：4

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