A GENERAL-METHOD FOR COUPLING UNPROTECTED PEPTIDES TO BROMOACETAMIDO PORPHYRIN TEMPLATES

被引：23

作者：

CHOMA, CT

KAESTLE, K

AKERFELDT, KS

KIM, RM

GROVES, JT

DEGRADO, WF

机构：

[1] DUPONT MERCK PHARMACEUT CO, EXPTL STN, WILMINGTON, DE 19880 USA

[2] PRINCETON UNIV, DEPT CHEM, PRINCETON, NJ 08544 USA

[3] RUTGERS STATE UNIV, DEPT CHEM, CAMDEN, NJ 08102 USA

[4] UNIV PENN, SCH MED, JOHNSON RES FDN, PHILADELPHIA, PA 19104 USA

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(00)73388-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An N-terminal cysteine is used to displace bromide from a bromoacetylated porphyrin to yield a thioether linkage between the peptide and the template. Unlike amide coupling reactions, this approach should be compatible with any peptide sequence provided there is only a single cysteine.

引用

收藏

页码：6191 / 6194

页数：4

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