INFLUENCE OF STEROID MEDICATION ON BONE-MINERAL DENSITY IN CHILDREN WITH NEPHROTIC SYNDROME

被引：59

作者：

LETTGEN, B

JEKEN, C

REINERS, C

机构：

[1] Department of Paediatric, University of Essen, Essen, 45122

[2] Department of Nuclear Medicine, University of Essen, Essen, 45122

来源：

PEDIATRIC NEPHROLOGY | 1994年 / 8卷 / 06期

关键词：

NEPHROTIC SYNDROME; STEROID THERAPY; CYCLOPHOSPHAMIDE; BONE MINERAL DENSITY; PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY;

D O I：

10.1007/BF00869084

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Bone mineral density (BMD) was studied in 26 children with idiopathic nephrotic syndrome and in age- and sex-matched healthy controls. BMD was selectively measured in trabecular (TBD), cortical (CBD) and total bone (ED) using peripheral quantitative computed tomography. Patients showed a decrease in ED, CBD and TBD. ED and CBD were inversely correlated with the cumulative dose of steroid treatment, Of the 26 patients with high cumulative doses of steroid, 16 were also treated with cyclophosphamide. In this group ED and CBD were decreased significantly compared with the children with a low cumulative steroid dose only. Compared with controls for each subgroup, significant decreases in ED, CBD and TBD were found in the group with high cumulative doses of steroids only. The higher cumulative steroid dose and the initial steroid toxicity which made cytotoxic therapy necessary, rather than cyclophosphamide itself, may be responsible for these findings.

引用

页码：667 / 670

页数：4

共 24 条

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