HUMAN PERIPHERAL-BLOOD EOSINOPHILS EXPRESS AND RELEASE INTERLEUKIN-8

被引：26

作者：

SIMON, HU

YOUSEFI, S

WEBER, M

SIMON, D

HOLZER, C

HARTUNG, K

BLASER, K

机构：

[1] KLIN DERMATOL & ALLERG,DAVOS,SWITZERLAND

[2] HOHENKLIN VALBELLA,DAVOS,SWITZERLAND

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 107卷 / 1-3期

关键词：

ASTHMA; ATOPIC DERMATITIS; CYTOKINES; EOSINOPHILS; INTERLEUKIN-8;

D O I：

10.1159/000236950

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Eosinophils can synthesize various cytokines. We demonstrate that interleukin-8 (IL-8) mRNA and protein are constitutively expressed by freshly isolated resting human eosinophils. Most of the patients with bronchial asthma or atopic dermatitis show evidence for up-regulated IL-8 protein expression in eosinophils but not in neutrophils, suggesting that an eosinophil-specific cytokine may act in these patients. To investigate whether the intracellular IL-8 can be released, eosinophils were stimulated by different cytokines and platelet-activating factor (PAF). Priming with granulocyte/macrophage-colory-stimulating factor and a subsequent 25-min stimulation with RANTES or PAF resulted in release of IL-8 from highly purified human eosinophils in vitro.

引用

页码：124 / 126

页数：3

共 7 条

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