A PROSPECTIVE SURVEY OF POSTOPERATIVE NAUSEA AND VOMITING WITH SPECIAL REGARD TO INCIDENCE AND RELATIONS TO PATIENT CHARACTERISTICS, ANESTHETIC ROUTINES AND SURGICAL-PROCEDURES

We performed a prospective study on 421 patients subjected to routine general-, orthopaedic-, urologic-, gynecological and paediatric surgery to estimate the current incidences of nausea and vomiting during the first 24 hours after surgery. The overall incidences of postoperative nausea or vomiting were 17% and 28%, respectively Postoperative emetic symptoms were not related to age in adults. Women had more often emetic symptoms than men (P<0.01). In general, opiate premedication was more frequently associated with postoperative nausea and vomiting than benzodiazepines (P<0.01), but in otherwise comparable subgroups of patients undergoing major surgery, this difference was not confirmed. Balanced general anaesthesia caused more nausea (23%) and vomiting (53%) than face-mask anaesthesia (13% and 15%, respectively) or regional blocks (12% and 7%, respectively) (P<0.001). There was a positive correlation between the duration of anaesthesia and the incidence of postoperative emetic symptoms (P<0.001). The incidences of postoperative nausea and vomiting after abdominal surgery were 23% and 58% respectively. Corresponding figures for orthopaedic surgery were 25% and 34%, other kinds of extraabdominal surgery 18% and 32% and for laparoscopy 21% and 25%. After minor gynecological-, urological and paediatric surgery the incidences were less than 20%. In conclusion female gender, balanced anaesthesia, lengthy duration of anaesthesia, and abdominal and orthopaedic operations appeared to be most frequently associated with postoperative emetic symptoms.