INTERACTION OF THE PROTEIN-KINASE RAF-1 WITH 14-3-3-PROTEINS

被引：262

作者：

FU, H

XIA, K

PALLAS, DC

CUI, C

CONROY, K

NARSIMHAN, RP

MAMON, H

COLLIER, RJ

ROBERTS, TM

机构：

[1] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV CELLULAR & MOLEC BIOL,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,BOSTON,MA 02115

[3] HARVARD UNIV,SCH MED,SHIPLEY INST MED,BOSTON,MA 02115

[4] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115

来源：

SCIENCE | 1994年 / 266卷 / 5182期

关键词：

D O I：

10.1126/science.7939632

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Members of a family of highly conserved proteins, termed 14-3-3 proteins, were found by several experimental approaches to associate with Raf-1, a central component of a key signal transduction pathway. Optimal complex formation required the amino-terminal regulatory domain of Raf-1. The association of 14-3-3 proteins and Raf-1 was not substantially affected by the activation state of Raf.

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页码：126 / 129

页数：4

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