MEASUREMENT OF ETHANOL IN THE HUMAN BRAIN USING NMR-SPECTROSCOPY

被引：34

作者：

HANSTOCK, CC ^{[1
]}

ROTHMAN, DL ^{[1
]}

SHULMAN, RG ^{[1
]}

NOVOTNY, EJ ^{[1
]}

PETROFF, OAC ^{[1
]}

PRICHARD, JW ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT APPL SCI MED,EDMONTON T6G 2G2,ALBERTA,CANADA

来源：

JOURNAL OF STUDIES ON ALCOHOL | 1990年 / 51卷 / 02期

关键词：

D O I：

10.15288/jsa.1990.51.104

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Ethanol in the human brain is readily observable by noninvasive 1H NMR spectroscopy. We have made such observations in a human subject with a time resolution per measurement of 6.5 min and volume resolution of 16 cc. The ethanol methyl proton signal is well separated from signals of other metabolites in 1H spectra from human brain and it is one of the most intense signals in such spectra when blood ethanol concentration is 0.1% (21.7 mM)- the legal definition of alcoholic intoxication in many jurisdictions. These properties, plus the fact that the ethanol signal can be further isolated from other resonances by spectral editing, open several possibilities for further investigation.

引用

页码：104 / 107

页数：4

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