SEMISYNTHETIC MODIFICATION OF HYGROMYCIN-A .1. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF VINYL METHYL AND AMIDE ANALOGS

被引：16

作者：

HECKER, SJ

MINICH, ML

WERNER, KM

机构：

[1] Pfizer Inc, Central Research Division, Groton

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)81192-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Formation of the peracetate of hygromycin A, followed by sodium borohydride reduction and oxidative cleavage, affords an aldehyde which serves as a key intermediate for preparation of vinyl methyl and amide analogs. Several analogs of each type were prepared and tested for activity against Serpulina hyodysenteriae, the causative organism of swine dysentery.

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页码：533 / 536

页数：4

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