PROTECTIVE OPSONIC ACTIVITY OF ANTIBODIES AGAINST FIBRONECTIN-BINDING PROTEINS (FNBPS) OF STAPHYLOCOCCUS-AUREUS

被引:30
作者
ROZALSKA, B
WADSTROM, T
机构
[1] UNIV LUND,DEPT MED MICROBIOL,SOLVEGATAN 23,S-22362 LUND,SWEDEN
[2] UNIV LODZ,INST MICROBIOL & IMMUNOL,DEPT INFECT BIOL,PL-90131 LODZ,POLAND
关键词
D O I
10.1111/j.1365-3083.1993.tb02574.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In this report, opsonic activity of hyperimmune rabbit IgG against fibronectin-binding proteins (gal-FnBP A and ZZ-FnBP B) of Staphylococcus aureus is described. Moreover, the action of IgG purified from serum of rabbits immunized with 'combined vaccine' (fibronectin-binding protein A+collagen-binding protein+alpha-toxoid) is shown. The opsonic activity has been studied in an in vitro phagocytosis assay as well as in vivo. Mice which had been infected intraperitoneally with S. aureus strain Cowan 1 pretreated (opsonized in vitro) with specific anti-FnBPs IgG were able to eliminate the staphylococci from the peritoneal cavity and liver more rapidly than controls. Also, clearance from the bloodstream of intravenously injected S. aureus Cowan 1 as well as S. aureus U320, opsonized with IgG anti-FnBPs or anti-FnBP+CnBP+alpha-toxoid, was more effective than observed in control groups. In other in vivo experiments it was shown that mice passively immunized with hyperimmune IgG anti-FnBP (one or two doses, intravenously) before challenge with S. aureus Cowan 1 eliminated the bacteria better than controls injected only with preimmune IgG.
引用
收藏
页码:575 / 580
页数:6
相关论文
共 26 条
[1]   GENETIC AND IMMUNOLOGICAL ANALYSIS OF MYCOBACTERIUM-TUBERCULOSIS FIBRONECTIN-BINDING PROTEINS [J].
ABOUZEID, C ;
GARBE, T ;
LATHIGRA, R ;
WIKER, HG ;
HARBOE, M ;
ROOK, GAW ;
YOUNG, DB .
INFECTION AND IMMUNITY, 1991, 59 (08) :2712-2718
[2]   CELL-SURFACE FIBRONECTIN OF MOUSE PERITONEAL-MACROPHAGES [J].
BEPPU, M ;
MASA, H ;
KIKUGAWA, K .
FEBS LETTERS, 1989, 242 (02) :378-382
[3]   FIBRONECTIN RECEPTORS OF PHAGOCYTES - CHARACTERIZATION OF THE ARG-GLY-ASP BINDING-PROTEINS OF HUMAN-MONOCYTES AND POLYMORPHONUCLEAR LEUKOCYTES [J].
BROWN, EJ ;
GOODWIN, JL .
JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (03) :777-793
[4]   ADHERENCE OF STAPHYLOCOCCUS-EPIDERMIDIS TO FIBRIN-PLATELET CLOTS INVITRO MEDIATED BY LIPOTEICHOIC ACID [J].
CHUGH, TD ;
BURNS, GJ ;
SHUHAIBER, HJ ;
BAHR, GM .
INFECTION AND IMMUNITY, 1990, 58 (02) :315-319
[5]  
CIBOROWSKI P, 1992, IN PRESS J MED MICRO, P37
[6]  
CZOP JK, 1985, J IMMUNOL, V134, P1844
[7]  
ESPERSEN F, 1984, ACTA PATH MICRO IM B, V92, P311
[8]  
ESPERSEN F, 1985, ACTA PATH MICRO IM C, V93, P53
[9]   CLONING AND EXPRESSION OF THE GENE FOR A FIBRONECTIN-BINDING PROTEIN FROM STAPHYLOCOCCUS-AUREUS [J].
FLOCK, JI ;
FROMAN, G ;
JONSSON, K ;
GUSS, B ;
SIGNAS, C ;
NILSSON, B ;
RAUCCI, G ;
HOOK, M ;
WADSTROM, T ;
LINDBERG, M .
EMBO JOURNAL, 1987, 6 (08) :2351-2357
[10]   POTENTIAL FOR VACCINATION AGAINST INFECTIONS CAUSED BY STAPHYLOCOCCUS-AUREUS [J].
FOSTER, TJ .
VACCINE, 1991, 9 (04) :221-227