SYNTHESIS AND BIOLOGICAL EFFECTS OF N-(2-PHOSPHONOMETHOXYETHYL) DERIVATIVES OF DEAZAPURINE BASES

被引：21

作者：

DVORAKOVA, H

HOLY, A

机构：

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1993年 / 58卷 / 06期

关键词：

D O I：

10.1135/cccc19931419

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Analogs of antiviral 9-(2-phosphonomethoxyethyl)adenine (PMEA, II), containing modified purine bases 1-deazaadenine (VII), 3-deazapurine (XI), 7-deaza-7-cyanoadenine (XIIIb) and 3-deazaguanine (XXIb), were prepared by alkylation of the heterocyclic bases with bis(2-propyl) 2-chloroethoxymethylphosphonate (V) in dimethylformamide in the presence of sodium hydride or cesium carbonate. The obtained protected derivatives were deblocked with bromotrimethylsilane to give the phosphonic acids. 3-DeazaPMEG (XXIb) is active against DNA viruses and exhibits a marked cytostatic effect against L-1210 leukemia.

引用

页码：1419 / 1429

页数：11

共 36 条

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