MODELS FOR RECOGNITION OF VIRALLY MODIFIED CELLS BY IMMUNE THYMUS-DERIVED LYMPHOCYTES

被引：119

作者：

DOHERTY, PC

GOTZE, D

TRINCHIERI, G

ZINKERNAGEL, RM

机构：

[1] UNIV PENN, WISTAR INST ANAT & BIOL, PHILADELPHIA, PA 19104 USA

[2] SCRIPPS CLIN & RES FDN, LA JOLLA, CA 92037 USA

来源：

IMMUNOGENETICS | 1976年 / 3卷 / 06期

关键词：

D O I：

10.1007/BF01576981

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Virus-immune effector T [thymus-derived] cells generated in vivo are specific for both the virus used and the H-2 type of the infected mouse. Genes mapping at H-2K or H-2D apparently as self markers. The mechanism underlying this function is not understood. Models that seem, at present, to be feasible explanations for this phenomenon are summarized. Possible implications of the hypothesis that self-recognition may be mediated by way of the same V gene subset that codes for alloreactivity are considered.

引用

页码：517 / 524

页数：8

共 30 条

[1] INTERACTION ANTIGENS DETECTED BY CYTOTOXIC-T-CELLS WITH MAJOR HISTOCOMPATIBILITY COMPLEX AS MODIFIER [J].