HUMAN PERFORIN (PRF1) MAPS TO 10Q22, A REGION THAT IS SYNTENIC WITH MOUSE CHROMOSOME-10

被引：23

作者：

FINK, TM

ZIMMER, M

WEITZ, S

TSCHOPP, J

JENNE, DE

LICHTER, P

机构：

[1] UNIV LAUSANNE, INST BIOCHEM, CH-1066 EPALINGES, SWITZERLAND

[2] MAX PLANCK INST EXPTL MED, MOLEK NEUROENDOKRINOL ABT, W-3400 GOTTINGEN, GERMANY

来源：

GENOMICS | 1992年 / 13卷 / 04期

关键词：

D O I：

10.1016/0888-7543(92)90050-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

Perforin (PRF1) is a cytolytic, channel-forming protein of cytolytic T cells, natural killer cells, and granulated metrial gland cells and plays a crucial role in the killer cell-mediated elimination of virally infected host cells tumor cells, and allotransplants. Two-thirds of the perforin sequence is homologous to the lytic, channel-forming complement proteins C6, C7, C8α, C8β, and C9. Using cosmid DNA containing the PRF1 gene as a probe for fluorescence in situ hybridization, we have reevaluated its chromosomal location. Previously assigned to chromosome 17q11-q21, it has now been mapped to 10q22. The human PRF1 locus lies within a conserved synteny segment present on mouse chromosome 10, consistent with the previous chromosomal assignment of mouse perforin. The perforin locus is not linked to any of the genes of the terminal complement system. © 1992.

引用

页码：1300 / 1302

页数：3

共 16 条

[1]

CONSTRUCTION AND CHARACTERIZATION OF PLASMID LIBRARIES ENRICHED IN SEQUENCES FROM SINGLE HUMAN-CHROMOSOMES [J].