OPTICAL COHERENCE TOMOGRAPHY

被引：12323

作者：

HUANG, D

SWANSON, EA

LIN, CP

SCHUMAN, JS

STINSON, WG

CHANG, W

HEE, MR

FLOTTE, T

GREGORY, K

PULIAFITO, CA

FUJIMOTO, JG

机构：

[1] MIT,DEPT ELECT ENGN & COMP SCI,CAMBRIDGE,MA 02139

[2] MIT,ELECTR RES LAB,CAMBRIDGE,MA 02139

[3] MIT,LINCOLN LAB,LEXINGTON,MA 02173

[4] HARVARD UNIV,SCH MED,DEPT OPHTHALMOL,BOSTON,MA 02115

[5] MASSACHUSETTS EYE & EAR HOSP,LASER RES LAB,BOSTON,MA 02114

[6] MASSACHUSETTS GEN HOSP,WELLMAN LABS,BOSTON,MA 02114

来源：

SCIENCE | 1991年 / 254卷 / 5035期

关键词：

D O I：

10.1126/science.1957169

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructure in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.

引用

页码：1178 / 1181

页数：4

共 39 条

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TIME-RESOLVED TRANSILLUMINATION FOR MEDICAL DIAGNOSTICS [J].