NUCLEOTIDIC PRODRUGS OF ANTI-HIV DIDEOXYNUCLEOSIDES

被引：15

作者：

PUECH, F

POMPON, A

LEFEBVRE, I

GOSSELIN, G

IMBACH, JL

机构：

[1] U.M.R. 112 Synthélabo - C.N.R.S.- Université Montpellier, 34095 Montpellier Cédex 5

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)81206-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dinucleoside phosphodi- and triester of ddC have been studied as potential prodrugs of the 5'-monophosphate nucleoside. Their kinetics of decomposition have been determined by HPLC in biological media using the "On-Line ISRP Cleaning" technique. From the results, it can be concluded that the anti-HIV activities of the dimeric compounds are mainly related to extracellular decomposition.

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页码：603 / 606

页数：4

相关论文

共 16 条

[1]

BLACKBURN GM, 1990, NUCLEIC ACIDS CHEM B, P71

[2]

BRUICE TC, 1966, BIOORG MECH, V2, P1

[3]

BUNDGAARD H, 1985, DESIGN PRODRUGS, P1

[4] SYNTHESIS AND BIOLOGICAL PROPERTIES OF NOVEL PHOSPHOTRIESTERS - A NEW APPROACH TO THE INTRODUCTION OF BIOLOGICALLY-ACTIVE NUCLEOTIDES INTO CELLS [J].

FARROW, SN ;

JONES, AS ;

KUMAR, A ;

WALKER, RT ;

BALZARINI, J ;

DECLERCQ, E .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (05) :1400-1406

[5]

HAHN EF, 1989, ACS SYM SER, V401, P156

[6] LIPOPHILIC GLYCOSYL PHOSPHOTRIESTER DERIVATIVES OF AZT - SYNTHESIS, NMR TRANSMEMBRANE TRANSPORT STUDY, AND ANTIVIRAL ACTIVITY [J].

HENIN, Y ;

GOUYETTE, C ;

SCHWARTZ, O ;

DEBOUZY, JC ;

NEUMANN, JM ;

HUYNHDINH, T .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (06) :1830-1837

[7] SYNTHESIS OF SIALIC ACID-CONTAINING NUCLEOTIDE SUGARS - CMP-SIALIC ACID ANALOGS [J].

IKEDA, K ;

NAGAO, Y ;

ACHIWA, K .

CARBOHYDRATE RESEARCH, 1992, 224 :123-131

[8] ATTEMPTS TO INTRODUCE CHEMOTHERAPEUTIC NUCLEOTIDES INTO CELLS - STUDIES ON THE ANTI-HIV AGENT FDT [J].

MCGUIGAN, C ;

JONES, BCNM ;

DEVINE, KG ;

NICHOLLS, SR ;

OCONNOR, TJ ;

KINCHINGTON, D .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1991, 1 (12) :729-732

[9] O-ALKYL-5',5'-DINUCLEOSIDE-PHOSPHATES AS COMBINED PRODRUGS OF ANTIVIRAL AND ANTIBIOTIC COMPOUNDS [J].

MEIER, C ;

HUYNHDINH, T .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1991, 1 (10) :527-530

[10] CONFORMATION AND INTERACTION OF DINUCLEOSIDE MONOPHOSPHATES AND DIPHOSPHATES .5. SYNTHESES AND PROPERTIES OF ADENINE AND THYMINE NUCLEOSIDE ALKYL PHOSPHOTRIESTERS, NEUTRAL ANALOGS OF DINUCLEOSIDE MONOPHOSPHATES [J].

MILLER, PS ;

FANG, KN ;

KONDO, NS ;

TSO, POP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (24) :6657-&