STRUCTURE/FUNCTION STUDIES OF LIN-12 NOTCH PROTEINS

被引：108

作者：

GREENWALD, I

机构：

[1] Howadd Hughes Medical Institute, Department of Biochemical and Molecular Biophysics, Columbia University, New York, NY 10032

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1994年 / 4卷 / 04期

关键词：

D O I：

10.1016/0959-437X(94)90072-B

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The lin-12/Notch proteins appear to act as transmembrane receptors for intercellular signals that specify cell fates during animal development. Recent structure/function studies have shown that the lin-12/Notch intracellular domain alone has the intrinsic signal-transducing activity of the intact protein, and that the role of the extracellular domain is to regulate this intrinsic activity. These studies have also suggested that the different lin-12/Notch proteins in a given organism are interchangeable biochemically and have addressed the role of lin-12/Notch genes in development.

引用

页码：556 / 562

页数：7

共 54 条

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