THE HUMAN EPISOME HALF1 - STRUCTURE OF ITS GENOMIC COUNTERPART

被引：3

作者：

BOCCACCIO, C ^{[1
]}

DESCHATRETTE, J ^{[1
]}

MEUNIERROTIVAL, M ^{[1
]}

机构：

[1] CNRS,INSERM,U347,F-94276 LE KREMLIN BICETR,FRANCE

来源：

GENETICA | 1994年 / 93卷 / 1-3期

关键词：

ALU AND L1HS REPEATS; HUMAN EPISOME; RETROPOSONS; RIBOSOMAL PROTEIN L21 PSEUDOGENE; SUBFAMILIES;

D O I：

10.1007/BF01435253

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A human episomal sequence (HALF1) has been identified by its ability to restore expression of hepatic functions when used to transfect a rat dedifferentiated cell line. The genomic equivalent of this human episome (gHALF1) and its flanking sequences were analyzed. HALF1 itself does not present the characteristics of a transposable element but half of its sequence corresponds to retroposons, including Alu and L1 repeats and a processed pseudogene, known to transpose via RNA intermediates. The structural characteristics of these different kinds of retroposons and their origin and evolution were analyzed.

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页码：217 / 224

页数：8

相关论文

共 30 条

[1] SEQUENTIAL INSERTION OF ALU FAMILY REPEATS INTO SPECIFIC GENOMIC SITES OF HIGHER PRIMATES [J].

BAILEY, AD ;

SHEN, CKJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) :7205-7209

[2] MAPPING THE WHOLE HUMAN GENOME BY FINGERPRINTING YEAST ARTIFICIAL CHROMOSOMES [J].

BELLANNECHANTELOT, C ;

LACROIX, B ;

OUGEN, P ;

BILLAULT, A ;

BEAUFILS, S ;

BERTRAND, S ;

GEORGES, I ;

GLIBERT, F ;

GROS, I ;

LUCOTTE, G ;

SUSINI, L ;

CODANI, JJ ;

GESNOUIN, P ;

POOK, S ;

VAYSSEIX, G ;

LUKUO, J ;

RIED, T ;

WARD, D ;

CHUMAKOV, I ;

LEPASLIER, D ;

BARILLOT, E ;

COHEN, D .

CELL, 1992, 70 (06) :1059-1068

[3] THE MOSAIC GENOME OF WARM-BLOODED VERTEBRATES [J].

BERNARDI, G ;

OLOFSSON, B ;

FILIPSKI, J ;

ZERIAL, M ;

SALINAS, J ;

CUNY, G ;

MEUNIERROTIVAL, M ;

RODIER, F .

SCIENCE, 1985, 228 (4702) :953-958

[4] EMPTY AND OCCUPIED INSERTION SITE OF THE TRUNCATED LINE-1 REPEAT LOCATED IN THE MOUSE SERUM ALBUMIN-ENCODING GENE [J].

BOCCACCIO, C ;

DESCHATRETTE, J ;

MEUNIERROTIVAL, M .

GENE, 1990, 88 (02) :181-186

[5]

BOCCACCIO C, 1994, CELL MOL GENET, V20, P163

[6] SOURCES AND EVOLUTION OF HUMAN ALU REPEATED SEQUENCES [J].

BRITTEN, RJ ;

BARON, WF ;

STOUT, DB ;

DAVIDSON, EH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (13) :4770-4774

[7]

DEININGER PL, 1992, TRENDS GENET, V8, P307, DOI 10.1016/0168-9525(92)90262-3

[8]

DESSEN P, 1990, COMPUT APPL BIOSCI, V6, P355

[9] ISOLATION OF AN ACTIVE HUMAN TRANSPOSABLE ELEMENT [J].

DOMBROSKI, BA ;

MATHIAS, SL ;

NANTHAKUMAR, E ;

SCOTT, AF ;

KAZAZIAN, HH .

SCIENCE, 1991, 254 (5039) :1805-1808

[10] L1 FAMILY OF REPETITIVE DNA-SEQUENCES IN PRIMATES MAY BE DERIVED FROM A SEQUENCE ENCODING A REVERSE TRANSCRIPTASE-RELATED PROTEIN [J].

HATTORI, M ;

KUHARA, S ;

TAKENAKA, O ;

SAKAKI, Y .

NATURE, 1986, 321 (6070) :625-628