EFFECT OF AFLATOXIN-B1 ON HUMAN PLATELET PROTEIN-KINASE-C

被引：6

作者：

VANDENHEEVER, LH ^{[1
]}

DIRR, HW ^{[1
]}

机构：

[1] RAND AFRIKAANS UNIV,DEPT BIOCHEM,JOHANNESBURG 2000,SOUTH AFRICA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1991年 / 23卷 / 09期

关键词：

D O I：

10.1016/0020-711X(91)90068-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Aflatoxin B1 serves as an activator for protein kinase C (PKC). 2. Following activation, the enzyme translocates from the cytosol to the particulate fraction. 3. Aflatoxin B1 leads to rapid and extensive phosphorylation of the known substrate of the enzyme. 4. Aflatoxin B1 causes rapid hydrolysis of phosphatidylinositol-4,5-biphosphate to diacylglycerol and inositol-1,4,5-triphosphate.

引用

页码：839 / 843

页数：5

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