AUTORADIOGRAPHIC ANALYSIS OF SEROTONIN 5-HT1A RECEPTOR-BINDING IN THE HUMAN BRAIN POSTMORTEM - EFFECTS OF AGE AND ALCOHOL

被引：181

作者：

DILLON, KA

GROSSISSEROFF, R

ISRAELI, M

BIEGON, A

机构：

[1] UNIV CALIF BERKELEY LAWRENCE BERKELEY LAB,DIV RES MED & RADIAT BIOPHYS,1 CYCLOTRON RD,BERKELEY,CA 94720

[2] NYU MED CTR,DEPT PSYCHIAT,NEW YORK,NY 10016

[3] WEIZMANN INST SCI,DEPT NEUROBIOL,IL-76100 REHOVOT,ISRAEL

来源：

BRAIN RESEARCH | 1991年 / 554卷 / 1-2期

关键词：

SEROTONIN RECEPTOR; HUMAN BRAIN; AUTORADIOGRAPHY;

D O I：

10.1016/0006-8993(91)90171-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Quantitative autoradiographic analysis of serotonin 5-HT1A receptors in the human brain, using [H-3]8-OH-DPAT as a ligand, reveals region-specific decreases in receptor labeling with age in several cortical and hippocampal regions and in the raphe nuclei. This is due to a change in receptor density (B(max)) with no apparent change in affinity (K(d)) as affirmed by saturation binding analysis on representative cortical regions. The presence of alcohol is associated with decreased binding in several cortical gyri. Suicide, gender and postmortem delay had no effect on 8-OH-DPAT binding.

引用

页码：56 / 64

页数：9

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