HYPOTHESIS - THE ELECTROCHEMICAL REGULATION OF METABOLISM

被引：4

作者：

BERRY, MN

GRIVELL, AR

PHILLIPS, JW

机构：

[1] Department of Medical Biochemistry, School of Medicine, The Flinders University of South Australia, Adelaide, South Australia, 5001

来源：

PURE AND APPLIED CHEMISTRY | 1993年 / 65卷 / 09期

关键词：

D O I：

10.1351/pac199365091957

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An Electrochemical model of metabolism is described that takes account of a variety of metabolic phenomena observed in our laboratory. These include a utilisation by hepatocytes of oxygen, substantially in excess of ATP requirements; energy-dependence of the [lactate]/[pyruvate] ratio; non-equilibrium behaviour of the components of the lactate dehydrogenase reaction during ethanol oxidation, and linear relationships between cellular potentials and metabolic fluxes. In the light of these findings, we propose as an extension of the Mitchell chemiosmotic hypothesis, that metabolic pathways are under the control of opposing far-from-equilibrium chemical and electrical forces that poise the pathways in a balanced state of apparent equilibrium, allowing flux to be regulated by changes in the magnitude of cellular potentials.

引用

页码：1957 / 1962

页数：6

共 39 条

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[2]

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[4] LINEAR RELATIONSHIPS BETWEEN MITOCHONDRIAL FORCES AND CYTOPLASMIC FLOWS ARGUE FOR THE ORGANIZED ENERGY-COUPLED NATURE OF CELLULAR-METABOLISM [J].

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[5] INTRACELLULAR MITOCHONDRIAL-MEMBRANE POTENTIAL AS AN INDICATOR OF HEPATOCYTE ENERGY-METABOLISM - FURTHER EVIDENCE FOR THERMODYNAMIC CONTROL OF METABOLISM [J].

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[6] REGULATORY ROLE OF REDUCING-EQUIVALENT TRANSFER FROM SUBSTRATE TO OXYGEN IN HEPATIC METABOLISM OF GLYCEROL AND SORBITOL [J].

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[8] THE CALORIGENIC NATURE OF HEPATIC KETOGENESIS - AN EXPLANATION FOR THE STIMULATION OF RESPIRATION INDUCED BY FATTY-ACID SUBSTRATES [J].

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[9] ENERGY-DEPENDENT REGULATION OF THE STEADY-STATE CONCENTRATIONS OF THE COMPONENTS OF THE LACTATE-DEHYDROGENASE REACTION IN LIVER [J].

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[10]

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