GLUCOCORTICOIDS MEDIATE THE STRESS-INDUCED EXTRACELLULAR ACCUMULATION OF GLUTAMATE

被引：316

作者：

MOGHADDAM, B ^{[1
]}

BOLINAO, ML ^{[1
]}

STEINBEHRENS, B ^{[1
]}

SAPOLSKY, R ^{[1
]}

机构：

[1] STANFORD UNIV,GILBERT LAB,DEPT BIOL SCI,STANFORD,CA 94305

来源：

BRAIN RESEARCH | 1994年 / 655卷 / 1-2期

关键词：

STRESS; GLUCOCORTICOID; GLUTAMATE; HIPPOCAMPUS; MICRODIALYSIS;

D O I：

10.1016/0006-8993(94)91622-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The hippocampal damage caused by stress has been attributed to an increased glutamatergic tone brought about by secretion of glucocorticoids. Although exposure to stress has been shown to increase the outflow of glutamate, direct involvement of glucocorticoid in this phenomenon has not been examined. The present study demonstrates that adrenalectomy attenuates the stress-induced outflow of glutamate in the hippocampus and prefrontal cortex and that glucocorticoid replacement abolishes this attenuation.

引用

页码：251 / 254

页数：4

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