ETHANOL INTEROCEPTIVE CUE AND SLEEP-TIME DURATION IN HAS AND LAS SELECTIVELY BRED RATS

被引：13

作者：

KRIMMER, EC

机构：

[1] Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 36卷 / 02期

关键词：

Alcohol; Drug discrimination; Ethanol; Exteroceptive cue; HAS; LAS; Selective breeding; Sleep-time;

D O I：

10.1016/0091-3057(90)90400-C

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The drug discrimination paradigm was used to evaluate the effects of selective breeding for differential sensitivity to the hypnotic effects of ethanol. Tenth generation high alcohol sensitive (HAS) and low alcohol sensitive (LAS) rats were trained to discriminate between ethanol (0.6 g/kg, IP) and saline vehicle on a VR-5 schedule of reinforcement. The animals were tested with 0.15, 0.3, and 0.9 g/kg ethanol following 40, 50, and 60 training sessions. Sleep-time, tested before and following discrimination training, did not change for the HAS and LAS animals. Dose-response functions showed differences between the HAS and LAS phenotypes after 40 training sessions but not after 50 sessions or after 60 sessions. © 1990.

引用

页码：255 / 260

页数：6

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