DIFFERENTIAL EXPRESSION OF TRANSLATION-ASSOCIATED GENES IN BENIGN AND MALIGNANT HUMAN BREAST-TUMORS

被引：29

作者：

ADAMS, SM ^{[1
]}

SHARP, MGF ^{[1
]}

WALKER, RA ^{[1
]}

BRAMMAR, WJ ^{[1
]}

VARLEY, JM ^{[1
]}

机构：

[1] UNIV LEICESTER, DEPT PATHOL, LEICESTER LE1 7RH, ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1992年 / 65卷 / 01期

关键词：

D O I：

10.1038/bjc.1992.12

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The human gene sequences encoding the translation-associated functions of alpha-subunit of elongation factor 1 (EF-1-alpha) and the ubiquitin carboxyl extension protein (HUBCEP80) have been isolated by differential cDNA screening, and found to have significantly higher levels of expression in fibroadenomas (benign) compared with carcinomas (malignant) of the breast. These data parallel our previous findings that the acidic ribosomal phosphoprotein P2 also has higher expression levels in the benign breast tumours (Sharp et al., 1990). In situ hybridisation has shown these genes to be expressed predominantly in the epithelium of breast tumours.

引用

页码：65 / 71

页数：7

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