HIV SEROCONVERSION IN INTRAVENOUS-DRUG-USERS IN SAN-FRANCISCO, 1985-1990

Objective: To examine the HIV seroconversion rate, risk factors for seroconversion, and changes in risk behavior over time in intravenous drug users (IVDU) in San Francisco, 1985-1990. Design: Observational study. Setting: All methadone maintenance and 21-day methadone detoxification programs in San Francisco. Participants: A total of 2351 heterosexual IVDU, of whom 681 were seronegative at first visit and seen at least twice ('repeaters'). Main outcome measures: HIV seroconversion rates, risk factors for seroconversion, and changes in behavior. Results: The HIV seroconversion rate in repeaters was 1.9% per person-year (ppy) of follow-up [2.1% in women versus 1.7% in men (not significant); 4% in African Americans versus 1% in whites (P=0.006); 3.9% ppy in the first third of the study, 1.2% in the second (P=0.007), and 1.9% in the last (not significant)]. Risk factors for seroconversion were five or more sexual partners per year [hazard ratio (HR)=2.6; P=0.02], use of shooting gallery ever (HR=2.9; P=0.02), and less than 1 year (lifetime) in methadone maintenance (HR=2.7; P=0.02). Self-reported intravenous cocaine use fell from 33 to 15% over 5 years, shooting gallery use fell from 19 to 6%, and the proportion with five or more sexual partners fell from 25 to 10%. Bleach use rose to 75% of needle-sharers. Conclusions: The 1985-1990 HIV seroconversion rate in IVDU (1.9% ppy) was comparable to that in San Francisco cohorts of homosexual men (1.4% ppy). A decline in HIV seroconversion coincided with changes in risk behavior. Stable attendance of methadone maintenance was highly protective: the seroconversion rate in subjects with 1 year or more in methadone was 12% ppy.