PARASITE LACTATE-DEHYDROGENASE AS AN ASSAY FOR PLASMODIUM-FALCIPARUM DRUG-SENSITIVITY

被引：666

作者：

MAKLER, MT ^{[1
]}

RIES, JM ^{[1
]}

WILLIAMS, JA ^{[1
]}

BANCROFT, JE ^{[1
]}

PIPER, RC ^{[1
]}

GIBBINS, BL ^{[1
]}

HINRICHS, DJ ^{[1
]}

机构：

[1] FLOW INC,PORTLAND,OR

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 1993年 / 48卷 / 06期

关键词：

D O I：

10.4269/ajtmh.1993.48.739

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This report compares the use of the lactate dehydrogenase (pLDH) assay with 3H-hypoxanthine incorporation and Giemsa microscopy for the evaluation of anti-malaria drug inhibition of the growth of P. falciparum in vitro. The inhibition profiles and IC50 determinations of the pLDH assay were directly comparable to those determined by the radioactive uptake and microscopic methods. Furthermore, the pLDH culture sensitivity assay is reproducible, easily interpreted, rapid and inexpensive to perform, suggesting field applicability.

引用

页码：739 / 741

页数：3

共 7 条

[1] QUANTITATIVE ASSESSMENT OF ANTI-MALARIAL ACTIVITY INVITRO BY A SEMIAUTOMATED MICRODILUTION TECHNIQUE [J].