THE TRANSMISSION OF FISH-PAINTED PATTERNS DERIVED FROM COMPLEX CHROMOSOME EXCHANGES

被引：34

作者：

SAVAGE, JRK

机构：

[1] MRC Radiobiology Unit, Chilton, Didcot

来源：

MUTATION RESEARCH LETTERS | 1995年 / 347卷 / 02期

关键词：

COMPLEX CHROMOSOME EXCHANGE; TRANSMISSION; FISH PAINTING;

D O I：

10.1016/0165-7992(95)90075-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The first 26 families of complex chromosome-type exchanges (from three breaks in two chromosomes to five breaks in five chromosomes) have been evaluated, and the 15 060 exchanges resulting from unrestricted restitution or rejoining of the break ends yields 203 distinctive patterns, if a single participating chromosome is FISH-painted. If we assume that any exchange that produces an acentric fragment of any sort (compound-terminal or interstitial) will be ultimately eliminated in a continuously dividing cell population, then, irrespective of family origin, only 17 of these patterns (approximate to 8%) will be transmitted, long-term. The 17 are illustrated, and the implications briefly discussed.

引用

页码：87 / 95

页数：9

共 20 条

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AWA AA, 1983, RAD INDUCED CHROMOSO, P433

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