THE IDENTIFICATION AND PURIFICATION OF THE HETEROTRIMERIC GTP-BINDING PROTEIN FROM SQUID (LOLIGO-FORBESI) PHOTORECEPTORS

被引:37
作者
POTTINGER, JDD [1 ]
RYBA, NJP [1 ]
KEEN, JN [1 ]
FINDLAY, JBC [1 ]
机构
[1] UNIV LEEDS,DEPT BIOCHEM & MOLEC BIOL,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND
关键词
D O I
10.1042/bj2790323
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The principal GTP-binding protein (G-protein) from squid (Loligo forbesi) photoreceptor membranes has been identified by amino acid sequencing. The heterotrimeric protein was purified by detergent solubilization and ion-exchange chromatography. The amino acid sequence of the G-protein alpha-subunit (G-alpha) indicates that this subunit is closely related to the recently characterized Gq subgroup, whereas the G-gamma subunit varies widely in sequence from other homologues.
引用
收藏
页码:323 / 326
页数:4
相关论文
共 35 条
[1]  
BAEHR W, 1982, J BIOL CHEM, V257, P6452
[2]  
BAER KM, 1988, J BIOL CHEM, V263, P17
[3]   ISOLATION OF A PUTATIVE PHOSPHOLIPASE-C GENE OF DROSOPHILA, NORPA, AND ITS ROLE IN PHOTOTRANSDUCTION [J].
BLOOMQUIST, BT ;
SHORTRIDGE, RD ;
SCHNEUWLY, S ;
PERDEW, M ;
MONTELL, C ;
STELLER, H ;
RUBIN, G ;
PAK, WL .
CELL, 1988, 54 (05) :723-733
[4]   MYOINOSITOL POLYPHOSPHATE MAY BE A MESSENGER FOR VISUAL EXCITATION IN LIMULUS PHOTORECEPTORS [J].
BROWN, JE ;
RUBIN, LJ ;
GHALAYINI, AJ ;
TARVER, AP ;
IRVINE, RF ;
BERRIDGE, MJ ;
ANDERSON, RE .
NATURE, 1984, 311 (5982) :160-163
[5]  
CERIONE RA, 1986, J BIOL CHEM, V261, P3901
[6]   COUPLING OF PHOTOEXCITED RHODOPSIN TO INOSITOL PHOSPHOLIPID HYDROLYSIS IN FLY PHOTORECEPTORS [J].
DEVARY, O ;
HEICHAL, O ;
BLUMENFELD, A ;
CASSEL, D ;
SUSS, E ;
BARASH, S ;
RUBINSTEIN, CT ;
MINKE, B ;
SELINGER, Z .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (19) :6939-6943
[7]   PHOTORECEPTOR EXCITATION AND ADAPTATION BY INOSITOL 1,4,5-TRISPHOSPHATE [J].
FEIN, A ;
PAYNE, R ;
CORSON, DW ;
BERRIDGE, MJ ;
IRVINE, RF .
NATURE, 1984, 311 (5982) :157-160
[8]   BLOCKADE OF VISUAL EXCITATION AND ADAPTATION IN LIMULUS PHOTORECEPTOR BY GDP-BETA-S [J].
FEIN, A .
SCIENCE, 1986, 232 (4757) :1543-1545
[9]  
FINDLAY JBC, 1989, PROTEIN SEQUENCING P, P69
[10]  
FUNG BKK, 1983, J BIOL CHEM, V258, P495