DELAYED-TYPE HYPERSENSITIVITY AND CELL-MEDIATED-IMMUNITY IN THE PATHOGENESIS OF TUBERCULOSIS

被引：241

作者：

DANNENBERG, AM ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,BALTIMORE,MD 21205

来源：

IMMUNOLOGY TODAY | 1991年 / 12卷 / 07期

关键词：

D O I：

10.1016/0167-5699(91)90035-R

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is widely believed that cell-mediated immunity and the associated ability of macrophages to destroy or inhibit the bacillus are all that is required to control pulmonary tuberculosis. However, although cell-mediated immunity is a major host defense against the tubercle bacillus, it is fully effective only in one of the four stages of the disease. Here, Arthur Dannenberg describes the entire pathogenesis of tuberculosis, with illustrations from the rabbit model of M.B. Lurie. In addition, he documents that the delayed-type hypersensitivity reaction (producing tissue necrosis) greatly benefits the host by arresting the logarithmic growth of bacilli within immature macrophages.

引用

页码：228 / 233

页数：6

共 43 条

[1] CHARACTERIZATION OF THE SECRETED ANTIGENS OF MYCOBACTERIUM-BOVIS BCG - COMPARISON OF THE 46-KILODALTON DIMERIC PROTEIN WITH PROTEINS MPB64 AND MPB70 [J].