LIDOCAINE BLOOD-LEVELS FOLLOWING AEROSOLIZATION AND INTRAVENOUS ADMINISTRATION

被引：9

作者：

BAUGHMAN, VL

LAURITO, CE

POLEK, WV

机构：

[1] Departments of Anesthesiology, Humana Hospital-Michael Reese and the University, Illinois College of Medicine, Chicago, IL

来源：

JOURNAL OF CLINICAL ANESTHESIA | 1992年 / 4卷 / 04期

关键词：

LIDOCAINE; INTRAVENOUS; AEROSOLIZED; SERUM CONCENTRATION; TOXICITY;

D O I：

10.1016/0952-8180(92)90139-R

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Study Objective: To determine whether, following aerosolization of lidocaine for topical airway anesthesia, intravenous (IV) lidocaine produces toxic lidocaine blood concentrations. Design: Randomized, double-blind study. Setting: University-affiliated hospital. Patients: Forty healthy patients scheduled for outpatient surgery. Interventions: The patients received in a randomized, double-blind manner aerosolized lidocaine or placebo followed 10 minutes later by IV lidocaine or placebo. Measurements and Main Results: After completion of lidocaine or placebo aerosolization and 2 minutes following IV administration of either lidocaine or the placebo, venous blood samples were obtained. Lidocaine concentration was measured using a homogenous enzyme assay. The group receiving both aerosolized and IV placebo and the group receiving aerosolized lidocaine and an IV placebo had undetectable (<0.05 mug/ml) serum lidocaine levels. The groups that received either an aerosolized placebo or aerosolized lidocaine and IV lidocaine had similar serum lidocaine concentrations [3.34 +/- 0.46 vs. 3.24 +/- 0.55 mug/ml (mean +/- SEM); p > 0.05 by Mann-Whitney U test]. Conclusion: IV lidocaine can be safely administered following aerosolization of lidocaine in spontaneously breathing patients without producing toxic blood lidocaine concentrations.

引用

页码：325 / 327

页数：3

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