CARDIOPROTECTIVE ACTIONS OF TRANSFORMING GROWTH-FACTOR-BETA

被引：18

作者：

ROBERTS, AB ^{[1
]}

SPORN, MB ^{[1
]}

LEFER, AM ^{[1
]}

机构：

[1] THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DEPT PHYSIOL,PHILADELPHIA,PA 19107

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1993年 / 3卷 / 03期

关键词：

D O I：

10.1016/1050-1738(93)90027-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Transforming growth factor-beta (TGF-beta) has been shown to have protective effects in experimental models of myocardial, mesenteric, and cerebral ischemia-reperfusion injury. These effects are mediated by its ability to block adhesion of neutrophils to endothelium and to preserve endothelial function in terms of physiologic release of nitric oxide (NO). TGF-beta also maintains the rhythmicity of cultured cardiac myocytes and blocks the suppressive effects of interleukin-1 on their beating rate by antagonizing the pathologic induction of NO synthase. These data suggest that TGF-beta will be useful clinically in treatment of both reperfusion injury and inflammatory diseases of the heart.

引用

页码：77 / 81

页数：5

共 41 条

[1]

AKHURST R J, 1990, Progress in Growth Factor Research, V2, P153, DOI 10.1016/0955-2235(90)90002-2

[2] TRANSFORMING GROWTH-FACTOR-BETA ATTENUATES ISCHEMIA-INDUCED ALTERATIONS IN CEREBROVASCULAR RESPONSES [J].

ARMSTEAD, WM ;

MIRRO, R ;

ZUCKERMAN, SL ;

SHIBATA, M ;

LEFFLER, CW .

AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 264 (02) :H381-H385

[3] CONTROL OF CARDIAC-MUSCLE CELL-FUNCTION BY AN ENDOGENOUS NITRIC-OXIDE SIGNALING SYSTEM [J].

BALLIGAND, JL ;

KELLY, RA ;

MARSDEN, PA ;

SMITH, TW ;

MICHEL, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (01) :347-351

[4]

FURUKAWA KI, 1991, J BIOL CHEM, V266, P12337

[5]

GAMBLE JR, 1988, SCIENCE, V242, P97

[6] INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR INHIBIT CARDIAC MYOCYTE BETA-ADRENERGIC RESPONSIVENESS [J].

GULICK, T ;

CHUNG, MK ;

PIEPER, SJ ;

LANGE, LG ;

SCHREINER, GF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (17) :6753-6757

[7] LOCALIZATION OF TRANSFORMING GROWTH FACTOR-BETA-1 IN MITOCHONDRIA OF MURINE HEART AND LIVER [J].

HEINE, UI ;

BURMESTER, JK ;

FLANDERS, KC ;

DANIELPOUR, D ;

MUNOZ, EF ;

ROBERTS, AB ;

SPORN, MB .

CELL REGULATION, 1991, 2 (06) :467-477

[8] INTERLEUKIN-1-BETA PREVENTS THE STIMULATORY EFFECT OF TRANSFORMING GROWTH-FACTOR-BETA ON COLLAGEN GENE-EXPRESSION IN HUMAN SKIN FIBROBLASTS [J].

HEINO, J ;

HEINONEN, T .

BIOCHEMICAL JOURNAL, 1990, 271 (03) :827-830

[9] TRANSFORMING GROWTH FACTOR-BETA-1-SPECIFIC BINDING-PROTEINS ON HUMAN VASCULAR ENDOTHELIAL-CELLS [J].

HIRAI, R ;

KAJI, K .

EXPERIMENTAL CELL RESEARCH, 1992, 201 (01) :119-125

[10] CARDIOPROTECTIVE EFFECTS OF AUTHENTIC NITRIC-OXIDE IN MYOCARDIAL-ISCHEMIA WITH REPERFUSION [J].

JOHNSON, G ;

TSAO, PS ;

LEFER, AM .

CRITICAL CARE MEDICINE, 1991, 19 (02) :244-252

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