Mitotic Origins of Chromosomal Instability in Colorectal Cancer

被引：11

作者：

Dalton, W. Brian ^{[1
]}

Yang, Vincent W. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Med, Div Digest Dis, 201 Whitehead Biomed Res Bldg,615 Michael St, Atlanta, GA 30322 USA

来源：

CURRENT COLORECTAL CANCER REPORTS | 2007年 / 3卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1007/s11888-007-0001-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mitosis is a crucial part of the cell cycle. A successful mitosis requires the proper execution of many complex cellular behaviors. Thus, there are many points at which mitosis may be disrupted. In cancer cells, chronic disruption of mitosis can lead to unequal segregation of chromosomes, a phenomenon known as chromosomal instability. A majority of colorectal tumors suffer from this instability, and recent studies have begun to reveal the specific ways in which mitotic defects promote chromosomal instability in colorectal cancer.

引用

页码：59 / 64

页数：6

共 49 条

[1] AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
Anand, S
Penrhyn-Lowe, S
Venkitaraman, AR
[J]. CANCER CELL, 2003, 3 (01) : 51 - 62
[2] Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation
Babu, JR
Jeganathan, KB
Baker, DJ
Wu, XS
Kang-Decker, N
van Deursen, JM
[J]. JOURNAL OF CELL BIOLOGY, 2003, 160 (03) : 341 - 353
[3] BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
Baker, DJ
Jeganathan, KB
Cameron, JD
Thompson, M
Juneja, S
Kopecka, A
Kumar, R
Jenkins, RB
de Groen, PC
Roche, P
van Deursen, JM
[J]. NATURE GENETICS, 2004, 36 (07) : 744 - 749
[4] G1 and G2 cell-cycle arrest following microtubule depolymerization in human breast cancer cells
Blajeski, AL
Phan, VA
Kottke, TJ
Kaufmann, SH
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (01) : 91 - 99
[5] Characterization of MAD2B and other mitotic spindle checkpoint genes
Cahill, DP
da Costa, LT
Carson-Walter, EB
Kinzler, KW
Vogelstein, B
Lengauer, C
[J]. GENOMICS, 1999, 58 (02) : 181 - 187
[6] Mutations of mitotic checkpoint genes in human cancers
Cahill, DP
Lengauer, C
Yu, J
Riggins, GJ
Willson, JKV
Markowitz, SD
Kinzler, KW
Vogelstein, B
[J]. NATURE, 1998, 392 (6673) : 300 - 303
[7] Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency
Dai, W
Wang, Q
Liu, TY
Swamy, M
Fang, YQ
Xie, SQ
Mahmood, R
Yang, YM
Xu, M
Ra, CV
[J]. CANCER RESEARCH, 2004, 64 (02) : 440 - 445
[8] Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells
Draviam, V. M.
Shapiro, I.
Aldridge, B.
Sorger, P. K.
[J]. EMBO JOURNAL, 2006, 25 (12) : 2814 - 2827
[9] Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human
Ewart-Toland, A
Briassouli, P
de Koning, JP
Mao, JH
Yuan, JW
Chan, F
MacCarthy-Morrogh, L
Ponder, BAJ
Nagase, H
Burn, J
Ball, S
Almeida, M
Linardopoulos, S
Balmain, A
[J]. NATURE GENETICS, 2003, 34 (04) : 403 - 412
[10] Mutations in the APC tumour suppressor gene cause chromosomal instability
Fodde, R
Kuipers, J
Rosenberg, C
Smits, R
Kielman, M
Gaspar, C
van Es, JH
Bruekel, C
Wiegant, J
Giles, RH
Clevers, H
[J]. NATURE CELL BIOLOGY, 2001, 3 (04) : 433 - 438

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