LOCALIZED EPILEPTIFORM ACTIVITY INDUCED BY MURINE CRF IN RATS

被引：42

作者：

MARROSU, F ^{[1
]}

FRATTA, W ^{[1
]}

CARCANGIU, P ^{[1
]}

GIAGHEDDU, M ^{[1
]}

GESSA, GL ^{[1
]}

机构：

[1] UNIV CAGLIARI, DEPT NEUROSCI, I-09124 CAGLIARI, ITALY

来源：

EPILEPSIA | 1988年 / 29卷 / 04期

关键词：

D O I：

10.1111/j.1528-1157.1988.tb03733.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Murine corticotropin releasing factor (rCRF), injected intracerebroventricularly into rats at a dose of 10 .mu.g produced increased motor activity, grooming, and recurrent episodes of epileptic activity localized in the hippocampal leads. Such activity persisted for .apprx. 5 h and was characterized by recurrent trains of biphasic spikes never associated with behavioral signs of epilepsy. The intraperitoneal administration of carbamazepine (15 and 30 mg/kg) reduced the epileptic activity for .apprx. 90 and 120 min, respectively, whereas that of naloxone (8 mg/kg) was ineffective. The results suggest that rCRF-induced spiking activity might be a model of temporal lobe epilepsy.

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收藏

页码：369 / 373

页数：5

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